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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/13750
Title: Electrochemical investigations of mometasone furoate, a topical corticosteroid, in micellar medium
Authors: Goyal R.N.
Kaur D.
Agrawal B.
Yadav S.K.
Published in: Journal of Electroanalytical Chemistry
Abstract: The electrochemical behavior of mometasone furoate (MF) has been studied at single-walled carbon nanotubes modified pyrolytic graphite electrode (MPG). Addition of cationic surfactant (cetyltrimethylammonium bromide, CTAB) was found to enhance the reduction current signal of MF, whereas, anionic (sodium dodecylsulfate, SDS) and non-ionic (Tween 60) surfactants exhibited opposite effect. A sensitive and selective electrochemical determination of mometasone furoate (MF) by square wave voltammetry and cyclic voltammetry in phosphate buffer of pH 7.2 has been carried out in the presence of CTAB. The cathodic peak current showed a linear response for MF reduction in the concentration range 10-1000 μM and using an electrode with effective surface area 0.225 cm 2, a sensitivity and detection limit of 0.017 μA/μM and 1.23 μM, respectively were observed. The reduction site in MF was established by the separation and characterization of the product of reduction by 1H NMR and FT-IR spectroscopic measurements and found to be carbonyl group at position 3. The developed method was successfully applied for the determination of MF in pharmaceutical preparations and in human urine. © 2013 Elsevier B.V. All rights reserved.
Citation: Journal of Electroanalytical Chemistry (2013), 695(): 17-23
URI: https://doi.org/10.1016/j.jelechem.2013.02.022
http://repository.iitr.ac.in/handle/123456789/13750
Issue Date: 2013
Publisher: Elsevier B.V.
Keywords: CTAB
Mometasone furoate
Pyrolytic graphite
SWCNT
Voltammetry
ISSN: 15726657
Author Scopus IDs: 7202793324
57198295473
57197605146
55499773200
Author Affiliations: Goyal, R.N., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India
Kaur, D., Department of Physics, Indian Institute of Technology Roorkee, Roorkee 247 667, India
Agrawal, B., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India
Yadav, S.K., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India
Funding Details: One of the authors (SKY) is thankful to the Council of Scientific and Industrial Research, New Delhi for the award of Junior Research Fellowship. Financial Assistance for this work was provided by CSIR, New Delhi vide Grant No. 01/2419/10-EMR-II .
Corresponding Author: Goyal, R.N.; Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India; email: rngcyfcy@iitr.ernet.in
Appears in Collections:Journal Publications [PH]

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