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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1363
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dc.contributor.authorSauraj-
dc.contributor.authorKumar S.U.-
dc.contributor.authorKumar V.-
dc.contributor.authorPriyadarshi R.-
dc.contributor.authorGopinath, Packirisamy-
dc.contributor.authorNegi, Yuvraj Singh-
dc.date.accessioned2020-09-30T11:38:58Z-
dc.date.available2020-09-30T11:38:58Z-
dc.date.issued2018-
dc.identifier.citationCarbohydrate Polymers(2018), 188(): 252-259-
dc.identifier.issn1448617-
dc.identifier.other29525163-
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2018.02.006-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/1363-
dc.description.abstractIn the present study, novel pH-responsive prodrug nanoparticles based on xylan-curcumin (xyl-cur) conjugate were developed to enhance the therapeutic efficacy of curcumin in cancer therapy. The synthesis of xyl-cur conjugate (prodrug) was confirmed by FT-IR, 1H NMR, UV–vis and fluorescence spectroscopy. The xyl-cur prodrug was subsequently self-assembled in to nanoparticles (xyl-cur prodrug NPs) in an aqueous medium with the average particle size 253 nm and the zeta potential of ?18.76 mV. The xyl-cur prodrug NPs were highly pH-sensitive in nature and most of the drug was released at lower pH. The interaction of the xyl-cur prodrug NPs with blood components was tested by hemolysis study. The cytotoxic activity of the xyl-cur prodrug NPs against human colon cancer cells (HT-29, HCT-15) demonstrated that the prodrug NPs exhibits greater cytotoxic effect than curcumin. Therefore, these results reveal that xyl-cur prodrug NPs could be a promising candidate for improving the intracellular delivery of curcumin in cancer therapy. © 2018 Elsevier Ltd-
dc.language.isoen_US-
dc.publisherElsevier Ltd-
dc.relation.ispartofCarbohydrate Polymers-
dc.subjectCell cytotoxicity-
dc.subjectCurcumin-
dc.subjectDrug-release-
dc.subjectHemocompatibility-
dc.subjectProdrug NPs-
dc.subjectXylan-
dc.titlepH-responsive prodrug nanoparticles based on xylan-curcumin conjugate for the efficient delivery of curcumin in cancer therapy-
dc.typeArticle-
dc.scopusid57192377506-
dc.scopusid55500572500-
dc.scopusid55605778846-
dc.scopusid57191968694-
dc.scopusid56242963200-
dc.scopusid6701821524-
dc.affiliationSauraj, Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India-
dc.affiliationKumar, S.U., Nanobiotechnology Laboratory, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Utta-
dc.description.fundingThe authors express their gratitude to Ministry of Human Resource Development (MHRD) , New Delhi for financial support to conduct the study. Sincere thanks to Department of Biotechnology, IIT Roorkee for the various biological facilities provided. Appendi-
dc.description.correspondingauthorNegi, Y.S.; Department of Polymer and Process Engineering, Indian Institute of Technology RoorkeeIndia; email: yuvrajnegi@gmail.com-
Appears in Collections:Journal Publications [BT]
Journal Publications [PE]

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