Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1363
Title: pH-responsive prodrug nanoparticles based on xylan-curcumin conjugate for the efficient delivery of curcumin in cancer therapy
Authors: Sauraj
Kumar S.U.
Kumar V.
Priyadarshi R.
Gopinath, Packirisamy
Negi, Yuvraj Singh.
Published in: Carbohydrate Polymers
Abstract: In the present study, novel pH-responsive prodrug nanoparticles based on xylan-curcumin (xyl-cur) conjugate were developed to enhance the therapeutic efficacy of curcumin in cancer therapy. The synthesis of xyl-cur conjugate (prodrug) was confirmed by FT-IR, 1H NMR, UV–vis and fluorescence spectroscopy. The xyl-cur prodrug was subsequently self-assembled in to nanoparticles (xyl-cur prodrug NPs) in an aqueous medium with the average particle size 253 nm and the zeta potential of ?18.76 mV. The xyl-cur prodrug NPs were highly pH-sensitive in nature and most of the drug was released at lower pH. The interaction of the xyl-cur prodrug NPs with blood components was tested by hemolysis study. The cytotoxic activity of the xyl-cur prodrug NPs against human colon cancer cells (HT-29, HCT-15) demonstrated that the prodrug NPs exhibits greater cytotoxic effect than curcumin. Therefore, these results reveal that xyl-cur prodrug NPs could be a promising candidate for improving the intracellular delivery of curcumin in cancer therapy. © 2018 Elsevier Ltd
Citation: Carbohydrate Polymers(2018), 188(): 252-259
URI: https://doi.org/10.1016/j.carbpol.2018.02.006
http://repository.iitr.ac.in/handle/123456789/1363
Issue Date: 2018
Publisher: Elsevier Ltd
Keywords: Cell cytotoxicity
Curcumin
Drug-release
Hemocompatibility
Prodrug NPs
Xylan
ISSN: 1448617
Author Scopus IDs: 57192377506
55500572500
55605778846
57191968694
56242963200
6701821524
Author Affiliations: Sauraj, Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Kumar, S.U., Nanobiotechnology Laboratory, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Utta
Funding Details: The authors express their gratitude to Ministry of Human Resource Development (MHRD) , New Delhi for financial support to conduct the study. Sincere thanks to Department of Biotechnology, IIT Roorkee for the various biological facilities provided. Appendi
Corresponding Author: Negi, Y.S.; Department of Polymer and Process Engineering, Indian Institute of Technology RoorkeeIndia; email: yuvrajnegi@gmail.com
Appears in Collections:Journal Publications [BT]
Journal Publications [PE]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.