http://repository.iitr.ac.in/handle/123456789/1363| Title: | pH-responsive prodrug nanoparticles based on xylan-curcumin conjugate for the efficient delivery of curcumin in cancer therapy |
| Authors: | Sauraj Kumar S.U. Kumar V. Priyadarshi R. Gopinath, Packirisamy Negi, Yuvraj Singh |
| Published in: | Carbohydrate Polymers |
| Abstract: | In the present study, novel pH-responsive prodrug nanoparticles based on xylan-curcumin (xyl-cur) conjugate were developed to enhance the therapeutic efficacy of curcumin in cancer therapy. The synthesis of xyl-cur conjugate (prodrug) was confirmed by FT-IR, 1H NMR, UV–vis and fluorescence spectroscopy. The xyl-cur prodrug was subsequently self-assembled in to nanoparticles (xyl-cur prodrug NPs) in an aqueous medium with the average particle size 253 nm and the zeta potential of ?18.76 mV. The xyl-cur prodrug NPs were highly pH-sensitive in nature and most of the drug was released at lower pH. The interaction of the xyl-cur prodrug NPs with blood components was tested by hemolysis study. The cytotoxic activity of the xyl-cur prodrug NPs against human colon cancer cells (HT-29, HCT-15) demonstrated that the prodrug NPs exhibits greater cytotoxic effect than curcumin. Therefore, these results reveal that xyl-cur prodrug NPs could be a promising candidate for improving the intracellular delivery of curcumin in cancer therapy. © 2018 Elsevier Ltd |
| Citation: | Carbohydrate Polymers(2018), 188(): 252-259 |
| URI: | https://doi.org/10.1016/j.carbpol.2018.02.006 http://repository.iitr.ac.in/handle/123456789/1363 |
| Issue Date: | 2018 |
| Publisher: | Elsevier Ltd |
| Keywords: | Cell cytotoxicity Curcumin Drug-release Hemocompatibility Prodrug NPs Xylan |
| ISSN: | 1448617 |
| Author Scopus IDs: | 57192377506 55500572500 55605778846 57191968694 56242963200 6701821524 |
| Author Affiliations: | Sauraj, Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India Kumar, S.U., Nanobiotechnology Laboratory, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Utta |
| Funding Details: | The authors express their gratitude to Ministry of Human Resource Development (MHRD) , New Delhi for financial support to conduct the study. Sincere thanks to Department of Biotechnology, IIT Roorkee for the various biological facilities provided. Appendi |
| Corresponding Author: | Negi, Y.S.; Department of Polymer and Process Engineering, Indian Institute of Technology RoorkeeIndia; email: yuvrajnegi@gmail.com |
| Appears in Collections: | Journal Publications [BT] Journal Publications [PE] |
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