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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1359
Title: Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis
Authors: Pal M.
Bhattacharya S.
Kalyan G.
Hazra S.
Published in: Experimental Cell Research
Abstract: The major hallmarks of Epithelial-Mesenchymal Transition (EMT) is the loss of epithelial cell polarity and loss of expression of the cell- cell adhesion molecule like E-cadherin and acquired mesenchymal cells marker called N-Cadherin. This phenotypical changes of E-M plasticity of cells is extensively considered to be a crucial factor for tumor cells invasion and cancer metastasis; landmark events for transforming a locally growing tumor (benign tumor) into a systemic and live-threatening disease (malignant tumor). Cadherin molecules are adherens junction proteins and expressed as multiple isoforms. Cadherin switching occurs during normal tissue developmental processes; also recapitulates the increasing aggressive behavior and metastatic nature of cancer cells when E-Cadherin converts to N-Cadherin, in particular. There are several mechanisms established that cadherin switching and some of the underlying pathways involves multiple steps associated with migration and invasion of cancer cells, and finally colonization of micro metastatic lesions to form macro-metastasis. Inhibition of metastasis is complicated by the plasticity of cancer cells behaviors and the evolving nature of microenvironment. Although there is no clear evidence how that dynamic structural switching of cadherin family member occurs, stabilized and eventually influence cell behavior, phenotypic transformations and initiate tumorigenesis. Therefore, we emphasize here the major functions of over 20 existing human cadherins in tissue integrity and stability as well as mechanistic understanding on recent work of cadherin ectodomain-mediated adhesion, functional studies of the cell-cell adhesion through key signaling intermediates interacting with other binding partners. We hope understanding on how the dynamic all existing cadherins influence the cell behavior can be targeted to design possible therapeutic interventions to combat its activity and prevent tumor cell growth, invasion and metastasis. © 2018 Elsevier Inc.
Citation: Experimental Cell Research (2018), 368(2): 137-146
URI: https://doi.org/10.1016/j.yexcr.2018.04.014
http://repository.iitr.ac.in/handle/123456789/1359
Issue Date: 2018
Publisher: Elsevier Inc.
Keywords: Cadherins
Cadherins switching
Cancer
Ectodomain
EMT
Interacting partners
Key signaling intermediates
ISSN: 144827
Author Scopus IDs: 56160237200
57202078739
57194140464
15837197000
Author Affiliations: Pal, M., Biotechnology Group, Biological Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam 785006, India, Academy of Scientific and Innovative Research (AcSIR), CSIR, North East Institute of Science and Technology, Jorhat, Assam 785006, India
Bhattacharya, S., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand 247667, India
Kalyan, G., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand 247667, India
Hazra, S., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee, Uttarakhand 247667, India
Corresponding Author: Pal, M.; Academy of Scientific & Innovative Research (AcSIR), Biological Sciences and Technology Division, CSIR-North East Institute of Science and TechnologyIndia; email: mpal24@yahoo.com
Appears in Collections:Journal Publications [BT]

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