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Title: Chemistry and biology of farnesol and its derivatives: Quorum sensing molecules with immense therapeutic potential
Authors: Gupta P.
Sharma M.
Arora N.
Pruthi V.
Poluri, Krishna Mohan
Published in: Current Topics in Medicinal Chemistry
Abstract: Background: Farnesol is an acyclic sesquiterpene alcohol, endogenously synthesized via the ergosterol pathway. It is a quorum sensing molecule (QSM) that was first discovered in C. albicans, and is involved in the inhibition of hyphae formation. Methods: This review focuses on the comprehensive details of occurrence, chemical/biological synthesis of farnesol and its derivatives, and the factors involved in the regulation of their production. Further, the review also presents their cellular functions and diversified biomedical applications. Results: Large-scale production of farnesol can be achieved using chemical synthesis and metabolic engineering approach. Farnesol is involved in the regulation of various physiological processes including filamentation, biofilm development, drug efflux, and apoptosis, etc. Farnesol and its derivatives/ analogues have also been reported to exhibit anti-biofilm, anti-cancer, anti-tumor and fungicidal properties. The antimicrobial potential of farnesol has been enhanced by synergizing it with known antifungal drugs, and also through nano-formulation(s). Conclusion: Apart from its quorum sensing activity, farnesol can be used as an effective anti-microbial, anti-inflammatory, ant-allergic, anti-cancerous, and anti-obesity agent. © 2018 Bentham Science Publishers.
Citation: Current Topics in Medicinal Chemistry(2018), 18(22): 1937-1954
Issue Date: 2018
Publisher: Bentham Science Publishers B.V.
Keywords: Antimicrobials
Molecular signaling
Quorum sensing
ISSN: 15680266
Author Scopus IDs: 56658955600
Author Affiliations: Gupta, P., Department of Biotechnology, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Sharma, M., Department of Biotechnology, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Ro
Funding Details: KMP acknowledges the support of DBT-IYBA fellowship –BT/07/IYBA/2013-19, SERB - SB/YS/LS-380/2013 Government of India. PG acknowledges the SERB-NPDF (PDF/2016/001670). MS and NA thank UGC and DBT for SRF Fellowship.
Corresponding Author: Poluri, K.M.; Department of Biotechnology, Indian Institute of Technology Roorkee (IIT-Roorkee)India; email:
Appears in Collections:Journal Publications [BT]

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