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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/13115
Title: Wear behavior and in vitro cytotoxicity of wear debris generated from hydroxyapatite-carbon nanotube composite coating
Authors: Lahiri, Debrupa
Benaduce A.P.
Rouzaud F.
Solomon J.
Keshri A.K.
Kos L.
Agarwal A.
Published in: Journal of Biomedical Materials Research - Part A
Abstract: This work evaluates the effect of carbon nanotube (CNT) addition to plasma-sprayed hydroxyapatite (HA) coating on its tribological behavior, biocompatibility of the coating, and cytotoxicity of CNT-containing wear debris. Biological response of the CNT-containing wear debris is critical for osteoblasts, the bone-forming cells, and macrophages, the cells that clear up wear debris from blood stream. The addition of 4 wt % CNTs to HA coating reduces the volume of wear debris generation by 80% because of the improved elastic modulus and fracture toughness. CNT reinforcement has a pronounced effect on the particle size in the wear debris and subsequent biological response. There was a slight increase in the numbers and viability of osteoblasts grown on HA-CNT compared with HA alone. The cytotoxic effect of HA and HA-CNT debris to macrophages and osteoblasts was similar, demonstrating that loose CNT does not pose a problem to these cells. © 2010 Wiley Periodicals, Inc.
Citation: Journal of Biomedical Materials Research - Part A (2011), 96 A(1): 1-12
URI: https://doi.org/10.1002/jbm.a.32952
http://repository.iitr.ac.in/handle/123456789/13115
Issue Date: 2011
Keywords: carbon nanotube
cytotoxicity
hydroxyapatite
macrophage
ostoeblast
wear debris
ISSN: 15493296
Author Scopus IDs: 26326345700
36636862400
6602452354
55480603500
35205917600
7004015655
7401480913
Author Affiliations: Lahiri, D., Plasma Forming Laboratory and High Temperature Tribology Laboratory, Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States
Benaduce, A.P., Biological Sciences, Florida International University, Miami, FL 33174, United States
Rouzaud, F., Biological Sciences, Florida International University, Miami, FL 33174, United States
Solomon, J., Plasma Forming Laboratory and High Temperature Tribology Laboratory, Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States, Materials Science and Engineering, University of Florida, Gainesville, FL 32611, United States
Keshri, A.K., Plasma Forming Laboratory and High Temperature Tribology Laboratory, Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States
Kos, L., Biological Sciences, Florida International University, Miami, FL 33174, United States
Agarwal, A., Plasma Forming Laboratory and High Temperature Tribology Laboratory, Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States
Corresponding Author: Agarwal, A.; Plasma Forming Laboratory and High Temperature Tribology Laboratory, Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States; email: agarwala@fiu.edu
Appears in Collections:Journal Publications [MT]

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