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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1288
Title: Carica papaya loaded poly (vinyl alcohol)-gelatin nanofibrous scaffold for potential application in wound dressing
Authors: Ahlawat J.
Kumar V.
Gopinath, Packirisamy
Published in: Materials Science and Engineering C
Abstract: Bioactive polymers are highly used polymers for preparing electrospun nanofiber based scaffold in the field of wound dressing to treat chronic non-healing wounds. Here, we report, the fabrication and evaluation of Carica papaya incorporated poly (vinyl) alcohol (PVA) blended gelatin nanofibers. PVA/Gelatin/Carica papaya nanofibrous scaffold was fabricated by electrospinning method. The obtained nanofibrous scaffold was characterized by using various analytical techniques such as FTIR, XRD, TEM, FESEM, AFM, and TGA. The average diameter of these nanofibers was found in the range 140–160 nm using FESEM. This scaffold showed excellent antibacterial activity against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria. The hemocompatibility was analyzed using platelet adhesion test. The cytotoxic activity of these nanofibrous scaffold against fibroblast cells (NIH 3T3) was studied and found no cytotoxic effect. Therefore, these results substantiated that Carica papaya loaded PVA/Gelatin nanofibrous scaffold could be a promising candidate for wound healing application. © 2019 Elsevier B.V.
Citation: Materials Science and Engineering C(2019), 103(): -
URI: https://doi.org/10.1016/j.msec.2019.109834
http://repository.iitr.ac.in/handle/123456789/1288
Issue Date: 2019
Publisher: Elsevier Ltd
Keywords: Carica papaya
Electrospinning
Nanofibrous scaffold
Polymers
Wound dressing
ISSN: 9284931
Author Scopus IDs: 57191415187
57208634573
56242963200
Author Affiliations: Ahlawat, J., Department of Biotechnology, Indian Institute of Technology Roorkee, India
Kumar, V., Department of Biotechnology, Indian Institute of Technology Roorkee, India
Gopinath, P., Department of Biotechnology, Indian Institute of Technology Roork
Funding Details: JA is thankful to the Department of Biotechnology, Government of India, for the fellowship. VK is thankful to the Ministry of Human Resource Development, Government of India, for the fellowship. Sincere thanks to Department of Chemistry and Institute Inst
Corresponding Author: Gopinath, P.; Department of Biotechnology, Indian Institute of Technology RoorkeeIndia; email: pgopifnt@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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