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Title: Differential in-vitro degradation and protein adhesion behaviour of SPS fabricated magnesium based temporary orthopaedic implant in serum and simulated body fluid
Authors: Jaiswal S.
Dubey A.
Haldar S.
Roy P.
 Lahiri D.
Published in: Biomedical Materials
Abstract: The interaction of proteins with implantable metallic surfaces has great influence on bioactivity and biodegradation of orthopaedic implants. Initial osseointegration is known to be critical for long term success of orthopaedic implants. The surface properties of the implant and electrochemical milieu of the surrounding solution, like, electrostatic, hydrophobic and hydrogen bonding interactions significantly modulate the protein adsorption by implants. Magnesium (Mg) is considered to improve the adhesion of osteoblasts via ligand binding of the integrin receptors. Mg based composites, reinforced with hydroxyapatite (HA), are potential candidates for temporary orthopaedic implants. However, their clinical translation requires enhanced degradation resistance in physiological environment, so that it is in sync with the healing rate of the bone. The present study deals with the protein adsorption characteristics and degradation behaviour of Mg-HA based biodegradable implants. Quantitative analysis of apatite inducing ability of composites was evaluated in terms of mass gain in simulated body fluid (SBF) as well as in fetal bovine serum (FBS), by in-vitro immersion study. Incorporation of 5 and 15 wt.% HA to Mg-3Zn improved apatite formation up to 35 and 66%, respectively, after 14 days of immersion in SBF. Compared to FBS, SBF is found significantly more effective in precipitating apatite on Mg-HA surface. However, FBS offered more corrosion resistance to Mg-HA, as compared to SBF, as evident from significant differences in protein adhesion capabilities of the composite surface when incubated separately in these two mediums. Addition of 15 wt.% HA has enhanced the protein adsorption capability by ~35%. These studies highlight the possibility to modulate the degradation and bioactivity of Mg based composite by tailoring the composition of HA. These findings, in turn, warrant the suitability of Mg-HA composite in orthopaedic application.
Citation: Biomedical Materials (2020), 15(): -
Issue Date: 2020
Appears in Collections:Journal Publications [MT]

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