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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/12624
Title: Boron nitride nanotube reinforced polylactide-polycaprolactone copolymer composite: Mechanical properties and cytocompatibility with osteoblasts and macrophages in vitro
Authors: Lahiri, Debrupa
Rouzaud F.
Richard T.
Keshri A.K.
Bakshi S.R.
Kos L.
Agarwal A.
Published in: Acta Biomaterialia
Abstract: Biodegradable polylactide-polycaprolactone copolymer (PLC) has been reinforced with 0, 2 and 5 wt.% boron nitride nanotubes (BNNTs) for orthopedic scaffold application. Elastic modulus of the PLC-5 wt.% BNNT composite, evaluated through nanoindentation technique, shows a 1370% increase. The same amount of BNNT addition to PLC enhances the tensile strength by 109%, without any adverse effect on the ductility up to 240% elongation. Interactions of the osteoblasts and macrophages with bare BNNTs prove them to be non-cytotoxic. PLC-BNNT composites displayed increased osteoblast cell viability as compared to the PLC matrix. The addition of BNNTs also resulted in an increase in the expression levels of the Runx2 gene, the main regulator of osteoblast differentiation. These results indicate that BNNT is a potential reinforcement for composites for orthopedic applications. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Citation: Acta Biomaterialia (2010), 6(9): 3524-3533
URI: https://doi.org/10.1016/j.actbio.2010.02.044
http://repository.iitr.ac.in/handle/123456789/12624
Issue Date: 2010
Publisher: Elsevier BV
Keywords: Biodegradable polymer composite
Boron nitride nanotube
Cytotoxicity
Mechanical properties
Viability
ISSN: 17427061
Author Scopus IDs: 26326345700
6602452354
36629317500
35205917600
24177950800
7004015655
7401480913
Author Affiliations: Lahiri, D., Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States
Rouzaud, F., Biological Sciences, Florida International University, Miami, FL 33174, United States
Richard, T., Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States
Keshri, A.K., Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States
Bakshi, S.R., Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States
Kos, L., Biological Sciences, Florida International University, Miami, FL 33174, United States
Agarwal, A., Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States
Funding Details: The authors thank Purac Biomaterials, Illinois, USA, for providing PLC copolymer for this research purpose. Ms. Sushmita Mustafi and Dr M.A. Barbieri, Biological Sciences at FIU are acknowledged for providing the murine macrophages. Mr. Geroge Gomes’s assistance during tensile testing and Dr. T. Kim’s valuable discussion are also acknowledged. The research facility at Advanced Materials Engineering and Research Institute (AMERI) in Florida International University, Dr. Y. Liu and Mr. Neal Ricks is also acknowledged for providing various characterization facilities. The authors are also thankful to the Centre for Study of Matters in Extreme Conditions (CeSMEC) and Dr. S. Saxena for extending the use of Micro-Raman Spectrometry facility for research purposes. A.A. acknowledges funding from the National Science Foundation CAREER Award (NSF-DMI-0547178) and Office of Naval Research-DURIP program (N00014-06-0675). Appendix Figures
Corresponding Author: Agarwal, A.; Mechanical and Materials Engineering, Florida International University, Miami, FL 33174, United States; email: agarwala@fiu.edu
Appears in Collections:Journal Publications [MT]

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