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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/12559
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dc.contributor.authorFeola A.-
dc.contributor.authorPal, Siladitya-
dc.contributor.authorMoalli P.-
dc.contributor.authorMaiti S.-
dc.contributor.authorAbramowitch S.-
dc.date.accessioned2020-10-15T12:24:07Z-
dc.date.available2020-10-15T12:24:07Z-
dc.date.issued2014-
dc.identifier.citationJournal of Biomechanics (2014), 47(11): 2584-2589-
dc.identifier.issn219290-
dc.identifier.other25011619-
dc.identifier.urihttps://doi.org/10.1016/j.jbiomech.2014.05.027-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/12559-
dc.description.abstractSynthetic polypropylene meshes were designed to restore pelvic organ support for women suffering from pelvic organ prolapse; however, the FDA released two notifications regarding potential complications associated with mesh implantation. Our aim was to characterize the structural properties of Restorelle and UltraPro subjected to uniaxial tension along perpendicular directions, and then model the tensile behavior of these meshes utilizing a co-rotational finite element model, with an imbedded linear or fiber-recruitment local stress-strain relationship. Both meshes exhibited a highly nonlinear stress-strain behavior; Restorelle had no significant differences between the two perpendicular directions, while UltraPro had a 93% difference in the low (initial) stiffness (p=0.009) between loading directions. Our model predicted that early alignment of the mesh segments in the loading direction and subsequent stretching could explain the observed nonlinear tensile behavior. However, a nonlinear stress-strain response in the stretching regime, that may be inherent to the mesh segment, was required to better capture experimental results. Utilizing a nonlinear fiber recruitment model with two parameters A and B, we observed improved agreement between the simulations and the experimental results. An inverse analysis found A=120. MPa and B=1.75 for Restorelle (RMSE=0.36). This approach yielded A=30. MPa and B=3.5 for UltraPro along one direction (RMSE=0.652), while the perpendicular orientation resulted in A=130. MPa and B=4.75 (RMSE=4.36). From the uniaxial protocol, Restorelle was found to have little variance in structural properties along these two perpendicular directions; however, UltraPro was found to behave anisotropically. © 2014 Elsevier Ltd.-
dc.language.isoen_US-
dc.publisherElsevier Ltd-
dc.relation.ispartofJournal of Biomechanics-
dc.subjectCo-rotational theorem-
dc.subjectFinite element model-
dc.subjectProlapse mesh-
dc.subjectStructural properties-
dc.subjectUniaxial tension-
dc.titleVarying degrees of nonlinear mechanical behavior arising from geometric differences of urogynecological meshes-
dc.typeArticle-
dc.scopusid24340574600-
dc.scopusid35321222100-
dc.scopusid6603029781-
dc.scopusid7202014965-
dc.scopusid6602313129-
dc.affiliationFeola, A., Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationPal, S., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationMoalli, P., Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationMaiti, S., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationAbramowitch, S., Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, United States-
dc.description.fundingThe financial support of the National Institutes of Health (NIH) R01 HD061811-01 .-
dc.description.correspondingauthorAbramowitch, S.; Department of Bioengineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, United States; email: sdast9@pitt.edu-
Appears in Collections:Journal Publications [ME]

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