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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/12559
Title: Varying degrees of nonlinear mechanical behavior arising from geometric differences of urogynecological meshes
Authors: Feola A.
Pal S.
Moalli P.
Maiti S.
Abramowitch S.
Published in: Journal of Biomechanics
Abstract: Synthetic polypropylene meshes were designed to restore pelvic organ support for women suffering from pelvic organ prolapse; however, the FDA released two notifications regarding potential complications associated with mesh implantation. Our aim was to characterize the structural properties of Restorelle and UltraPro subjected to uniaxial tension along perpendicular directions, and then model the tensile behavior of these meshes utilizing a co-rotational finite element model, with an imbedded linear or fiber-recruitment local stress-strain relationship. Both meshes exhibited a highly nonlinear stress-strain behavior; Restorelle had no significant differences between the two perpendicular directions, while UltraPro had a 93% difference in the low (initial) stiffness (p=0.009) between loading directions. Our model predicted that early alignment of the mesh segments in the loading direction and subsequent stretching could explain the observed nonlinear tensile behavior. However, a nonlinear stress-strain response in the stretching regime, that may be inherent to the mesh segment, was required to better capture experimental results. Utilizing a nonlinear fiber recruitment model with two parameters A and B, we observed improved agreement between the simulations and the experimental results. An inverse analysis found A=120. MPa and B=1.75 for Restorelle (RMSE=0.36). This approach yielded A=30. MPa and B=3.5 for UltraPro along one direction (RMSE=0.652), while the perpendicular orientation resulted in A=130. MPa and B=4.75 (RMSE=4.36). From the uniaxial protocol, Restorelle was found to have little variance in structural properties along these two perpendicular directions; however, UltraPro was found to behave anisotropically. © 2014 Elsevier Ltd.
Citation: Journal of Biomechanics (2014), 47(11): 2584-2589
URI: https://doi.org/10.1016/j.jbiomech.2014.05.027
http://repository.iitr.ac.in/handle/123456789/12559
Issue Date: 2014
Publisher: Elsevier Ltd
Keywords: Co-rotational theorem
Finite element model
Prolapse mesh
Structural properties
Uniaxial tension
ISSN: 219290
Author Scopus IDs: 24340574600
35321222100
6603029781
7202014965
6602313129
Author Affiliations: Feola, A., Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States
Pal, S., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States
Moalli, P., Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, United States
Maiti, S., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States
Abramowitch, S., Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, United States
Funding Details: The financial support of the National Institutes of Health (NIH) R01 HD061811-01 .
Corresponding Author: Abramowitch, S.; Department of Bioengineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, United States; email: sdast9@pitt.edu
Appears in Collections:Journal Publications [ME]

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