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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1250
Title: Efflux pump inhibitors for bacterial pathogens: From bench to bedside
Authors: Sharma A.
Gupta V.K.
Pathania R.
Published in: Indian Journal of Medical Research
Abstract: With the advent of antibiotics, bacterial infections were supposed to be a thing of past. However, this instead led to the selection and evolution of bacteria with mechanisms to counter the action of antibiotics. Antibiotic efflux is one of the major mechanisms, whereby bacteria pump out the antibiotics from their cellular interior to the external environment using special transporter proteins called efflux pumps. Inhibiting these pumps seems to be an attractive strategy at a time when novel antibiotic supplies are dwindling. Molecules capable of inhibiting these pumps, known as efflux pump inhibitors (EPIs), have been viewed as potential therapeutic agents that can rejuvenate the activity of antibiotics that are no longer effective against bacterial pathogens. EPIs follow some general mechanisms of efflux inhibition and are derived from various natural as well as synthetic sources. This review focuses on EPIs and identifies the challenges that have kept these futuristic therapeutics away from the commercial realm so far. © 2019 Indian Journal of Medical Research.
Citation: Indian Journal of Medical Research (2019), 149(2): 129-145
URI: https://doi.org/10.4103/ijmr.IJMR_2079_17
http://repository.iitr.ac.in/handle/123456789/1250
Issue Date: 2019
Publisher: Wolters Kluwer Medknow Publications
Keywords: Antibiotics
efflux pumps
multiple drug resistance
pathogens
therapeutics
ISSN: 9715916
Author Scopus IDs: 57217481823
57196262614
7004308029
Author Affiliations: Sharma, A., Department of Biotechnology, Indian Institute of Technology, Roorkee, Haridwar, Uttarakhand 247 667, India
Gupta, V.K., Department of Biotechnology, Indian Institute of Technology, Roorkee, Haridwar, Uttarakhand 247 667, India
Pathania, R., Department of Biotechnology, Indian Institute of Technology, Roorkee, Haridwar, Uttarakhand 247 667, India
Funding Details: Authors thank the Indian Council of Medical Research, New Delhi for financial support (Research grant No. AMR/15/2011-ECD-I), which led to the discovery of IITR08027, a novel EPI.
Corresponding Author: Pathania, R.; Department of Biotechnology, Indian Institute of TechnologyIndia; email: ranjanapathania@gmail.com
Appears in Collections:Journal Publications [BT]

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