Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1238
Title: Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin
Authors: Kaur R.
Neetu
Mudgal R.
Jose J.
Kumar, Pravindra R.Manish
Tomar, Shailly
Published in: Virology
Abstract: Highly pathogenic alphaviruses display complex glycans on their surface. These glycans play a crucial role in viral pathogenesis by facilitating glycan-host interaction during viral entry which can be targeted. Various studies have reported antiviral activity of lectins that bind to the glycans present on the surface of enveloped viruses. This study evaluates the antiviral potential of a chitinase (chi)-like lectin from Tamarind (TCLL) having specificity for N-acetylglucosamine (NAG). Thus, TCLL might bind to N-glycan rich surface of alphavirus and inhibit the entry of virus into the host cells. The direct treatment of TCLL with virus reduced the virus infection. Remarkably, the addition of NAG to TCLL abolished antiviral activity confirming that NAG binding property of TCLL is accountable for its antiviral activity. Further, an ELISA assay confirmed the binding of TCLL to alphaviruses. Taken together, this study will prove to be beneficial in developing lectin therapeutics targeting alphavirus glycan. © 2018 Elsevier Inc.
Citation: Virology(2019), 526(): 91-98
URI: https://doi.org/10.1016/j.virol.2018.10.009
http://repository.iitr.ac.in/handle/123456789/1238
Issue Date: 2019
Publisher: Academic Press Inc.
Keywords: Alphavirus
Chikungunya virus
Chitinase (chi)-like lectin
Lectin therapeutics
N-glycans
ISSN: 426822
Author Scopus IDs: 57213732771
57193241611
57195322398
7102211781
55064809000
57203506001
Author Affiliations: Kaur, R., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Neetu, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Mudgal, R., Department of Biotechnology, Indian In
Funding Details: This research was supported by the Department of Biotechnology ( DBT ), New Delhi, India [grant number: BT/PR21935/NNT/28/1217/2017 ]. R.K. thanks University Grant Commission ( UGC ), India; Neetu and R.M. thank Council of Scientific and Industrial Resear
Corresponding Author: Tomar, S.; Department of Biotechnology, Indian Institute of Technology RoorkeeIndia; email: shailfbt@iitr.ac.in
Appears in Collections:Journal Publications [BT]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.