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Title: Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin
Authors: Kaur R.
Mudgal R.
Jose J.
Kumar, Pravindra R.Manish
Tomar, Shailly
Published in: Virology
Abstract: Highly pathogenic alphaviruses display complex glycans on their surface. These glycans play a crucial role in viral pathogenesis by facilitating glycan-host interaction during viral entry which can be targeted. Various studies have reported antiviral activity of lectins that bind to the glycans present on the surface of enveloped viruses. This study evaluates the antiviral potential of a chitinase (chi)-like lectin from Tamarind (TCLL) having specificity for N-acetylglucosamine (NAG). Thus, TCLL might bind to N-glycan rich surface of alphavirus and inhibit the entry of virus into the host cells. The direct treatment of TCLL with virus reduced the virus infection. Remarkably, the addition of NAG to TCLL abolished antiviral activity confirming that NAG binding property of TCLL is accountable for its antiviral activity. Further, an ELISA assay confirmed the binding of TCLL to alphaviruses. Taken together, this study will prove to be beneficial in developing lectin therapeutics targeting alphavirus glycan. © 2018 Elsevier Inc.
Citation: Virology(2019), 526(): 91-98
Issue Date: 2019
Publisher: Academic Press Inc.
Keywords: Alphavirus
Chikungunya virus
Chitinase (chi)-like lectin
Lectin therapeutics
ISSN: 426822
Author Scopus IDs: 57213732771
Author Affiliations: Kaur, R., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Neetu, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Mudgal, R., Department of Biotechnology, Indian In
Funding Details: This research was supported by the Department of Biotechnology ( DBT ), New Delhi, India [grant number: BT/PR21935/NNT/28/1217/2017 ]. R.K. thanks University Grant Commission ( UGC ), India; Neetu and R.M. thank Council of Scientific and Industrial Resear
Corresponding Author: Tomar, S.; Department of Biotechnology, Indian Institute of Technology RoorkeeIndia; email:
Appears in Collections:Journal Publications [BT]

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