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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/12300
Title: Seasonal Variation in the Prevalence of Sand Flies Infected with Leishmania donovani
Authors: Tiwary P.
Kumar D.
Mishra M.
Singh R.P.
Rai M.
Sundar S.
Published in: PLoS ONE
Abstract: Background: Visceral Leishmaniasis (VL) is a life threatening neglected infectious disease in the Indian subcontinent, transmitted by the bite of female sand flies. Estimation of the infectivity in the vector population, collected in different seasons, may be useful to better understanding the transmission dynamics of VL as well as to plan vector control measures. Methodology: We collected sand flies from highly endemic regions of Bihar state, India for one year over three seasons. The species of the sand flies were confirmed by species-specific PCR-RFLP. Leishmania donovani infection was investigated in 1397 female Phlebotomus argentipes using PCR, targeting the Leishmania specific minicircle of the kDNA region. Further, the parasitic load in the infected sand flies was measured using quantitative PCR. Conclusion: Though sand flies were most abundant in the rainy season, the highest rate of infection was detected in the winter season with 2.84% sand flies infected followed by the summer and rainy seasons respectively. This study can help in vector elimination programmes and to reduce disease transmission. © 2013 Tiwary et al.
Citation: PLoS ONE (2013), 8(4): -
URI: https://doi.org/10.1371/journal.pone.0061370
http://repository.iitr.ac.in/handle/123456789/12300
Issue Date: 2013
ISSN: 19326203
Author Scopus IDs: 37123153500
57202478211
8608377500
55728382300
7007100331
7103328080
Author Affiliations: Tiwary, P., Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Kumar, D., Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Mishra, M., Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Singh, R.P., Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Rai, M., Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Sundar, S., Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Corresponding Author: Sundar, S.; Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India; email: doctorshyamsundar@gmail.com
Appears in Collections:Journal Publications [ME]

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