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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1206
Title: Backbone resonance assignments of the dimeric domain of the p50 NF-kappaB subunit
Authors: Kumar M.
Dadhwal P.
Atreya H.S.
Mukherjee S.P.
Published in: Biomolecular NMR Assignments
Abstract: The Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) is a family of transcription factor recognizing a 9–11 base pair kappaB sites on the promoter/enhancer region of their target genes. The family comprises of five members forming dimers amongst themselves in various combinations. Here we report the backbone resonance assignments of the 24 kDa homodimer of the p50 subunit of NF-kappaB. This is the first step towards understanding the mechanism of dimer formation in solution. The secondary structure derived from the chemical shifts for the dimer is largely consistent with that observed in the available crystal structures of the protein in DNA-bound form. © 2019, Springer Nature B.V.
Citation: Biomolecular NMR Assignments (2020), 14(1): 9-11
URI: https://doi.org/10.1007/s12104-019-09912-y
http://repository.iitr.ac.in/handle/123456789/1206
Issue Date: 2020
Publisher: Springer
Keywords: NF-kB
p50
Transcription factor
ISSN: 18742718
Author Scopus IDs: 57203422851
57210799758
6603471305
8655211900
Author Affiliations: Kumar, M., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Dadhwal, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India, Department of Biological Sciences, Columbia University, New York, NY 10027, United States
Atreya, H.S., NMR Research Centre, Indian Institute of Science Bangalore, Bangalore, Karnataka, India
Mukherjee, S.P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Funding Details: This work was funded by the Young Scientist Start-up (YSS) grant of the Science and Engineering Research Board (SERB), India (Grant #YSS/2015/000090) and the Faculty Initiation Grant (FIG) of the IITR to SPM, and UGC fellowship to MK (Award #330773). The NMR facilities at NMR Research Centre, Indian Institute of Science Bangalore and the National Facility for High Field NMR Facility at Tata Institute of Fundamental Research (TIFR), Mumbai are acknowledged.
Corresponding Author: Mukherjee, S.P.; Department of Biotechnology, Indian Institute of Technology RoorkeeIndia; email: mukherji.fbt@iitr.ac.in
Appears in Collections:Journal Publications [BT]

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