Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1192
Title: Targeted bioimaging and sensing of folate receptor-positive cancer cells using folic acid-conjugated sulfur-doped graphene quantum dots
Authors: Kadian S.
Manik, Gaurav
Das N.
Roy, Partha
Published in: Microchimica Acta
Abstract: For the first time is reported a facile in situ synthesis of folic acid-conjugated sulfur-doped graphene quantum dots (FA-SGQDs) through simple pyrolysis of citric acid (CA), 3-mercaptopropionic acid (MPA), and FA. The as-prepared FA-SGQDs were extensively characterized to confirm the synthesis and incidence of FA molecule on the surface of SGQDs through advanced characterization techniques. Upon excitation at 370-nm wavelength, FA-SGQDs exhibited blue fluorescence with an emission band at 455 nm. While exhibiting relatively high quantum yield (~ 78%), favorable biocompatibility, excellent photostability, and desirable optical properties, the FA-SGQDs showed suitability as a fluorescent nanoprobe to distinguish the folate receptor (FR)-positive and FR-negative cancer cells. The experimental studies revealed that FA-SGQDs aptly entered into FR-positive cancer cells via a non-immunogenic FR-mediated endocytosis process. Additionally, the FA-SGQDs exhibited excellent free radical scavenging activity. Hence, these FA-SGQDs hold high promise to serve as efficient fluorescent nanoprobes for the pre-diagnosis of cancer through targeted bioimaging and other pertinent biological studies. [Figure not available: see fulltext.] © 2020, Springer-Verlag GmbH Austria, part of Springer Nature.
Citation: Microchimica Acta (2020), 187(8): -
URI: https://doi.org/10.1007/s00604-020-04448-8
http://repository.iitr.ac.in/handle/123456789/1192
Issue Date: 2020
Publisher: Springer
Keywords: Cancer diagnosis
Fluorescent nanoprobe
Folate receptor
Folic acid-conjugated sulfur-doped graphene quantum dots (FA-SGQDs)
Targeted bioimaging
ISSN: 263672
Author Scopus IDs: 57203985194
56595314900
57209505172
35509207200
Author Affiliations: Kadian, S., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India
Manik, G., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India
Das, N., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India
Roy, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India
Funding Details: The first author thankfully acknowledges the MHRD, Government of India, for facilitating the doctoral scholarship. Authors sincerely thank the staff of the Centre of Nanotechnology and Institute Instrumentation Centre (IIC), IIT Roorkee, for helping in advanced characterizations.
Corresponding Author: Manik, G.; Department of Polymer and Process Engineering, Indian Institute of Technology RoorkeeIndia; email: gaurav.manik@pe.iitr.ac.in
Appears in Collections:Journal Publications [BT]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.