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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/11808
Title: Magnesium alloys as a biomaterial for degradable craniofacial screws
Authors: Henderson S.E.
Verdelis K.
Maiti S.
Pal S.
Chung W.L.
Chou D.-T.
Kumta P.N.
Almarza A.J.
Published in: Acta Biomaterialia
Abstract: Recently, magnesium (Mg) alloys have received significant attention as potential biomaterials for degradable implants, and this study was directed at evaluating the suitability of Mg for craniofacial bone screws. The objective was to implant screws fabricated from commercially available pure Mg and alloy AZ31 in vivo in a rabbit mandible. First, Mg and AZ31 screws were compared to stainless steel screws in an in vitro pull-out test and determined to have a similar holding strength (∼40 N). A finite-element model of the screw was created using the pull-out test data, and this model can be used for future Mg alloy screw design. Then, Mg and AZ31 screws were implanted for 4, 8 and 12 weeks, with two controls of an osteotomy site (hole) with no implant and a stainless steel screw implanted for 12 weeks. Microcomputed tomography was used to assess bone remodeling and Mg/AZ31 degradation, both visually and qualitatively through volume fraction measurements for all time points. Histological analysis was also completed for the Mg and AZ31 at 12 weeks. The results showed that craniofacial bone remodeling occurred around both Mg and AZ31 screws. Pure Mg had a different degradation profile than AZ31; however, bone growth occurred around both screw types. The degradation rate of both Mg and AZ31 screws in the bone marrow space and the muscle were faster than in the cortical bone space at 12 weeks. Furthermore, it was shown that by alloying Mg, the degradation profile could be changed. These results indicate the promise of using Mg alloys for craniofacial applications. © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Citation: Acta Biomaterialia (2014), 10(5): 2323-2332
URI: https://doi.org/10.1016/j.actbio.2013.12.040
http://repository.iitr.ac.in/handle/123456789/11808
Issue Date: 2014
Publisher: Elsevier BV
Keywords: Biodegradable metal
Craniofacial implants
Finite-element modeling
Magnesium
ISSN: 17427061
Author Scopus IDs: 52163558500
6507492984
7202014965
35321222100
35723900800
54396733900
55663968300
6507163758
Author Affiliations: Henderson, S.E., Department of Bioengineering, University of Pittsburgh, 566 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, United States
Verdelis, K., Department of Restorative Dentistry/Comprehensive Care, University of Pittsburgh, Pittsburgh, PA, United States
Maiti, S., Department of Bioengineering, University of Pittsburgh, 566 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, United States
Pal, S., Department of Bioengineering, University of Pittsburgh, 566 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, United States
Chung, W.L., Oral and Maxillofacial Surgery, University of Pittsburgh, Pittsburgh, PA, United States
Chou, D.-T., Department of Bioengineering, University of Pittsburgh, 566 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, United States
Kumta, P.N., Department of Bioengineering, University of Pittsburgh, 566 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, United States, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Almarza, A.J., Department of Bioengineering, University of Pittsburgh, 566 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, United States, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Funding Details: We would like to acknowledge J. Andrew Holmes at the University of Pittsburgh SCPI for screw fabrication. We would also like to acknowledge funding from the National Science Foundation under grant no. 0812348 , as well as from the National Institutes of Health under grant no. T32 EB003392-01 , and the University of Pittsburgh School of Dental Medicine. P.N.K. would also like to acknowledge support from the Edward R. Weildein Chair Professorship and the Center for Complex Engineered Multifunctional Materials (CCEMM) at the University of Pittsburgh. Appendix A
Corresponding Author: Almarza, A.J.; Department of Bioengineering, University of Pittsburgh, 566 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, United States; email: aja19@pitt.edu
Appears in Collections:Journal Publications [ME]

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