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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/11676
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dc.contributor.authorChaya A.-
dc.contributor.authorYoshizawa S.-
dc.contributor.authorVerdelis K.-
dc.contributor.authorMyers N.-
dc.contributor.authorCostello B.J.-
dc.contributor.authorChou D.-T.-
dc.contributor.authorPal, Siladitya-
dc.contributor.authorMaiti S.-
dc.contributor.authorKumta P.N.-
dc.contributor.authorSfeir C.-
dc.date.accessioned2020-10-15T12:19:41Z-
dc.date.available2020-10-15T12:19:41Z-
dc.date.issued2015-
dc.identifier.citationActa Biomaterialia (2015), 18(): 262-269-
dc.identifier.issn17427061-
dc.identifier.other25712384-
dc.identifier.urihttps://doi.org/10.1016/j.actbio.2015.02.010-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/11676-
dc.description.abstractEach year, millions of Americans suffer bone fractures, often requiring internal fixation. Current devices, like plates and screws, are made with permanent metals or resorbable polymers. Permanent metals provide strength and biocompatibility, but cause long-term complications and may require removal. Resorbable polymers reduce long-term complications, but are unsuitable for many load-bearing applications. To mitigate complications, degradable magnesium (Mg) alloys are being developed for craniofacial and orthopedic applications. Their combination of strength and degradation make them ideal for bone fixation. Previously, we conducted a pilot study comparing Mg and titanium devices with a rabbit ulna fracture model. We observed Mg device degradation, with uninhibited healing. Interestingly, we observed bone formation around degrading Mg, but not titanium, devices. These results highlighted the potential for these fixation devices. To better assess their efficacy, we conducted a more thorough study assessing 99.9% Mg devices in a similar rabbit ulna fracture model. Device degradation, fracture healing, and bone formation were evaluated using microcomputed tomography, histology and biomechanical tests. We observed device degradation throughout, and calculated a corrosion rate of 0.40 ± 0.04 mm/year after 8 weeks. In addition, we observed fracture healing by 8 weeks, and maturation after 16 weeks. In accordance with our pilot study, we observed bone formation surrounding Mg devices, with complete overgrowth by 16 weeks. Bend tests revealed no difference in flexural load of healed ulnae with Mg devices compared to intact ulnae. These data suggest that Mg devices provide stabilization to facilitate healing, while degrading and stimulating new bone formation.-
dc.language.isoen_US-
dc.publisherElsevier Ltd-
dc.relation.ispartofActa Biomaterialia-
dc.subjectFixation devices-
dc.subjectFracture fixation-
dc.subjectMagnesium-
dc.subjectMicroCT-
dc.titleIn vivo study of magnesium plate and screw degradation and bone fracture healing-
dc.typeArticle-
dc.scopusid26532444900-
dc.scopusid22939649200-
dc.scopusid6507492984-
dc.scopusid56536158200-
dc.scopusid7005935484-
dc.scopusid54396733900-
dc.scopusid35321222100-
dc.scopusid7202014965-
dc.scopusid55663968300-
dc.scopusid6602739502-
dc.affiliationChaya, A., Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationYoshizawa, S., Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationVerdelis, K., Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationMyers, N., Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationCostello, B.J., Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States, Department of Oral and Maxillofacial Surgery, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationChou, D.-T., Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationPal, S., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationMaiti, S., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationKumta, P.N., Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States-
dc.affiliationSfeir, C., Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States-
dc.description.fundingThis study was supported by the National Science Foundation Engineering Research Center for Revolutionizing Metallic Biomaterials (Grant 0812348 ), the Commonwealth of Pennsylvania ( SAP4100061184 ), the University of Pittsburgh’s Center for Craniofacial Regeneration , and PNK acknowledges the Edward R. Weidlein Chair Professorship funds from the Swanson School of Engineering, University of Pittsburgh. The authors would like to thank Andrew Holmes (University of Pittsburgh) for device fabrication, Dr. Michael Epperly (University of Pittsburgh) for device sterilization, and Dr. Alejandro Almarza (University of Pittsburgh) for assistance with mechanical testing. Appendix A-
dc.description.correspondingauthorSfeir, C.3501 Terrace St., 598 Salk Hall, United States-
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