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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1161
Title: Synthesis and cytotoxicity of novel (E)-2-phenylchroman-4-one-O-((1-substituted-1H-1,2,3-triazol-4-yl)methyl) oxime derivatives
Authors: Gutam M.
Mokenapelli S.
Yerrabelli J.R.
Banerjee S.
Roy, Partha
Chitneni P.R.
Published in: Synthetic Communications
Abstract: A series of new flavanone-triazole hybrids (7a–m) were synthesized from flavanone oximes (6a–c) via multistep synthetic strategy, involving Cu (I) catalyzed azide, alkyne 1,3-dipolar cycloaddition by Click reaction. All the synthesized compounds were tested for their cytotoxicity against HCT-15, HeLa, NCI-H522, and HEK-293 (normal cell line) cell lines. Compounds 6a, 7a, 7b, 7d, 7e, 7j, and 7m showed the significant cytotoxicity, wherein compound 7b showed potential cytotoxicity against NCI-H522 cell line and compounds 6a and 7a were offensive with HEK-293 in their toxicity profile. © 2020, © 2020 Taylor & Francis Group, LLC.
Citation: Synthetic Communications (2020), 50(12): 1883-1891
URI: https://doi.org/10.1080/00397911.2020.1759645
http://repository.iitr.ac.in/handle/123456789/1161
Issue Date: 2020
Publisher: Taylor and Francis Inc.
Keywords: 123-triazoles
13-dipolar cycloaddition
Cytotoxicity
flavanone
ISSN: 397911
Author Scopus IDs: 57208392278
57208399637
57209466768
57192818131
35509207200
56568248700
Author Affiliations: Gutam, M., Department of Chemistry, Natural Products Laboratory, Osmania University, Hyderabad, Telangana, India
Mokenapelli, S., Department of Chemistry, Natural Products Laboratory, Osmania University, Hyderabad, Telangana, India
Yerrabelli, J.R., Department of Chemistry, Natural Products Laboratory, Osmania University, Hyderabad, Telangana, India
Banerjee, S., Department of Biotechnology, Molecular Endocrinology Laboratory, Indian Institute of Technology, Roorkee, Uttarakhand, India
Roy, P., Department of Biotechnology, Molecular Endocrinology Laboratory, Indian Institute of Technology, Roorkee, Uttarakhand, India
Chitneni, P.R., Department of Chemistry, Natural Products Laboratory, Osmania University, Hyderabad, Telangana, India
Funding Details: GM thanks to the UGC-New Delhi, India, for providing Senior Research fellowship, Head Department of Chemistry and CFRD, Osmania University, Hyderabad, India for providing laboratory facilities and spectral data.
Corresponding Author: Chitneni, P.R.; Department of Chemistry, Natural Products Laboratory, Osmania UniversityIndia; email: prasadraoou@yahoo.com
Appears in Collections:Journal Publications [BT]

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