http://repository.iitr.ac.in/handle/123456789/1161| Title: | Synthesis and cytotoxicity of novel (E)-2-phenylchroman-4-one-O-((1-substituted-1H-1,2,3-triazol-4-yl)methyl) oxime derivatives |
| Authors: | Gutam M. Mokenapelli S. Yerrabelli J.R. Banerjee S. Roy, Partha Chitneni P.R. |
| Published in: | Synthetic Communications |
| Abstract: | A series of new flavanone-triazole hybrids (7a–m) were synthesized from flavanone oximes (6a–c) via multistep synthetic strategy, involving Cu (I) catalyzed azide, alkyne 1,3-dipolar cycloaddition by Click reaction. All the synthesized compounds were tested for their cytotoxicity against HCT-15, HeLa, NCI-H522, and HEK-293 (normal cell line) cell lines. Compounds 6a, 7a, 7b, 7d, 7e, 7j, and 7m showed the significant cytotoxicity, wherein compound 7b showed potential cytotoxicity against NCI-H522 cell line and compounds 6a and 7a were offensive with HEK-293 in their toxicity profile. © 2020, © 2020 Taylor & Francis Group, LLC. |
| Citation: | Synthetic Communications (2020), 50(12): 1883-1891 |
| URI: | https://doi.org/10.1080/00397911.2020.1759645 http://repository.iitr.ac.in/handle/123456789/1161 |
| Issue Date: | 2020 |
| Publisher: | Taylor and Francis Inc. |
| Keywords: | 123-triazoles 13-dipolar cycloaddition Cytotoxicity flavanone |
| ISSN: | 397911 |
| Author Scopus IDs: | 57208392278 57208399637 57209466768 57192818131 35509207200 56568248700 |
| Author Affiliations: | Gutam, M., Department of Chemistry, Natural Products Laboratory, Osmania University, Hyderabad, Telangana, India Mokenapelli, S., Department of Chemistry, Natural Products Laboratory, Osmania University, Hyderabad, Telangana, India Yerrabelli, J.R., Department of Chemistry, Natural Products Laboratory, Osmania University, Hyderabad, Telangana, India Banerjee, S., Department of Biotechnology, Molecular Endocrinology Laboratory, Indian Institute of Technology, Roorkee, Uttarakhand, India Roy, P., Department of Biotechnology, Molecular Endocrinology Laboratory, Indian Institute of Technology, Roorkee, Uttarakhand, India Chitneni, P.R., Department of Chemistry, Natural Products Laboratory, Osmania University, Hyderabad, Telangana, India |
| Funding Details: | GM thanks to the UGC-New Delhi, India, for providing Senior Research fellowship, Head Department of Chemistry and CFRD, Osmania University, Hyderabad, India for providing laboratory facilities and spectral data. |
| Corresponding Author: | Chitneni, P.R.; Department of Chemistry, Natural Products Laboratory, Osmania UniversityIndia; email: prasadraoou@yahoo.com |
| Appears in Collections: | Journal Publications [BT] |
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