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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1159
Title: Synthesis of bis-acridine derivatives exhibiting anticancer and anti-inflammatory activity
Authors: Sondhi S.M.
Kumar S.
Rani R.
Chakraborty A.
Roy P.
Published in: Journal of Heterocyclic Chemistry
Abstract: A series of bis-acridine derivatives 3a-j and 5a-j have been synthesized by condensation of 9-chloro-2,4-(un)substituted acridines (1a-e) and 9-isothiocyanato-2,4-(un)substituted acridines (4a-e) with diamine 2a and 2b, respectively. These bis-acridines were evaluated in vitro for activity against a panel of human cancer cell lines of lung (NCI H-522), ovary (PA1), breast (T47D), colon (HCT-15), and liver (HepG2). Several bis-acridines were found to possess good anticancer activity against various cancer cell lines. Of these, compound 3h exhibited good anticancer activity against all cancer cell lines tested except liver (HepG2) cell line. In addition to this, these compounds were screened for anti-inflammatory activity at a dose of 50 mg/kg p.o. Compound 3g exhibited 41% anti-inflammatory activity, which is better than most commonly used standard drug ibuprofen, which showed 39% anti-inflammatory (at 50 mg/kg p. o.) activity. © 2013 HeteroCorporation.
Citation: Journal of Heterocyclic Chemistry (2013), 50(2): 252-260
URI: https://doi.org/10.1002/jhet.985
http://repository.iitr.ac.in/handle/123456789/1159
Issue Date: 2013
ISSN: 0022152X
Author Scopus IDs: 7006090710
57216459762
16507511200
8507454000
35509207200
Author Affiliations: Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Uttarakhand, Roorkee 247667, India
Kumar, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Uttarakhand, Roorkee 247667, India
Rani, R., Department of Chemistry, Indian Institute of Technology-Roorkee, Uttarakhand, Roorkee 247667, India
Chakraborty, A., Department of Biotechnology, Indian Institute of Technology-Roorkee, Uttarakhand, Roorkee 247667, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Uttarakhand, Roorkee 247667, India
Corresponding Author: Department of Chemistry, Indian Institute of Technology-Roorkee, Uttarakhand, Roorkee 247667, India
Appears in Collections:Journal Publications [BT]

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