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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1149
Title: Synthesis, anti-inflammatory, and anticancer activity evaluation of some heterocyclic amidine and bis-amidine derivatives
Authors: Sondhi S.M.
Rani R.
Roy, Partha
Agrawal S.K.
Saxena A.K.
Published in: Journal of Heterocyclic Chemistry
Abstract: Figure represented. Heterocyclic amidine derivatives of benzothiazole (6a-c), benzimidazole (6d-f), benzoxazole (6g-i), and bis-amidine derivatives of pyrimidine, (7a, 7b) & triazole (7c-e) ring system have been synthesized by nucleophilic addition reaction. All these compounds were screened for anti-inflammatory and anticancer activities. At a dose of 50 mg/kg p.o., compounds 6c (39%), 6e (39%), and 6f (39%) exhibited anti-inflammatory activity comparable to standard drug ibuprofen, which showed 39% activity and compounds 6b, 6e, 7a, and 7c exhibited moderate anticancer activity against cervix (HELA); neuroblastoma (IMR-32); breast (MCF-7), leukemia (THP-1); and cervix (HELA) human cancer cell lines, respectively. © 2011 HeteroCorporation.
Citation: Journal of Heterocyclic Chemistry (2011), 48(4): 921-926
URI: https://doi.org/10.1002/jhet.658
http://repository.iitr.ac.in/handle/123456789/1149
Issue Date: 2011
ISSN: 0022152X
Author Scopus IDs: 7006090710
16507511200
35509207200
24173353300
7401482447
Author Affiliations: Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, Uttarakhand, India
Rani, R., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, Uttarakhand, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247667, Uttarakhand, India
Agrawal, S.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu 180001, India
Saxena, A.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu 180001, India
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, Uttarakhand, India; email: sondifcy@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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