Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/11283
Title: Effect of dietary administration of letrozole and tamoxifen on gonadal development, sex differentiation and biochemical changes in common carp (Cyprinus carpio L.)
Authors: Singh A.K.
Srivastava P.P.
Verma R.
Srivastava S.C.
Kumar D.
Ansari A.
Published in: Reproduction, Fertility and Development
Abstract: The effect of letrozole and tamoxifen on the specific growth rate (SGR; % day-1), gonado-somatic index (GSI), total haemoglobin (g%), gonadal and serum protein as well as lipid, sex differentiation and 17β-oestradiol levels were studied in sexually undifferentiated Cyprinus carpio fingerlings 30 days post fertilisation (30 dpf) for 60 days. Results showed decreased GSI with tamoxifen treatment whereas letrozole increased it. There were reduced protein, lipid, triglyceride and cholesterol levels after treatment with tamoxifen and letrozole during gonadal development. Tamoxifen (200 mg kg-1 feed) induced 82.5% masculinisation, whereas letrozole in the same dose produced 98.5% males. Gonadal 17β-oestradiol significantly declined from 86.0±1.41 pg per 100 mg (control) to 45.5±1.94 pg per 100 mg with tamoxifen and 36.0±0.72 pg per 100 mg with letrozole treatment. Similarly, serum 17β-oestradiol levels also decreased after tamoxifen and letrozole treatments. Testicular development in 37.8% of fish treated with tamoxifen and letrozole was found to be more advanced (spermatocytes) than in the control (spermatogonium); however, there was reduced ovarian growth and increased atresia. It was concluded that letrozole and tamoxifen both significantly affect sex differentiation and gonadal maturity in C. carpio leading to the production of sex-reversed males, yet the effect of letrozole was more potent. © 2015 CSIRO.
Citation: Reproduction, Fertility and Development (2015), 27(3): 449-457
URI: https://doi.org/10.1071/RD13234
http://repository.iitr.ac.in/handle/123456789/11283
Issue Date: 2015
Publisher: CSIRO
Keywords: 17β-oestradiol
aromatase
ISSN: 10313613
Author Scopus IDs: 55757781657
7202310793
56549422500
56663620600
57202478211
55388773100
Author Affiliations: Singh, A.K., Exotic Germplasm Section, Fish Health Management Division, National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow (Uttar Pradesh), 226002, India
Srivastava, P.P., Biochemistry and Genomics Laboratory, Molecular Biology and Biotechnology Division, National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow, (Uttar Pradesh), 226002, India
Verma, R., Exotic Germplasm Section, Fish Health Management Division, National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow (Uttar Pradesh), 226002, India
Srivastava, S.C., Exotic Germplasm Section, Fish Health Management Division, National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow (Uttar Pradesh), 226002, India
Kumar, D., Exotic Germplasm Section, Fish Health Management Division, National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow (Uttar Pradesh), 226002, India
Ansari, A., Exotic Germplasm Section, Fish Health Management Division, National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, Lucknow (Uttar Pradesh), 226002, India
Corresponding Author: Singh, A.K.; Exotic Germplasm Section, Fish Health Management Division, National Bureau of Fish Genetic Resources, Canal Ring Road, P.O. Dilkusha, India
Appears in Collections:Journal Publications [ME]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.