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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/11257
Title: Effect of aneurysm on biomechanical properties of "radially-oriented" collagen fibers in human ascending thoracic aortic media
Authors: Tsamis A.
Pal, Siladitya
Phillippi J.A.
Gleason T.G.
Maiti S.
Vorp D.A.
Published in: Journal of Biomechanics
Abstract: We recently reported a mechanistic model to link micro-architectural information to the delamination strength (Sd) of human ascending thoracic aorta (ATA). That analysis demonstrated that the number density (N) and failure energy (Uf) of the radially-oriented collagen fibers contribute to the Sd of both aneurysmal (ATAA) and non-aneurysmal (CTRL-ATA) aortic tissue. Among the set of ATAA samples, we studied specimens from patients displaying bicuspid (BAV) and tricuspid aortic valve (TAV) morphologic phenotypes. Results from our prior work were based on the assumption that the Uf was independent of dissection direction. In the current study, we excluded that assumption and hypothesized that Uf correlates with the Sd of ATAA. To test the hypothesis, we used previously-reported experimentally-determined Sd measurements and N of radially-oriented collagen fibers as input in our validated mechanistic model to calculate Uf for BAV-ATAA, TAV-ATAA and CTRL-ATA tissue specimens. The results of our analysis revealed that Uf is significantly lower for both BAV-ATAA and TAV-ATAA compared to CTRL-ATA cases, and does not differ between BAV-ATAA and TAV-ATAA. Furthermore, we found that Uf is consistent between circumferential-radial and longitudinal-radial planes in either of BAV-ATAA, TAV-ATAA or CTRL-ATA specimens. These findings employ a novel mechanistic model to increase our understanding of the putative interrelationship between biomechanical properties, extracellular matrix biology, and failure energy of aortic dissection. © 2014 Elsevier Ltd.
Citation: Journal of Biomechanics (2014), 47(16): 3820-3824
URI: https://doi.org/10.1016/j.jbiomech.2014.10.024
http://repository.iitr.ac.in/handle/123456789/11257
Issue Date: 2014
Publisher: Elsevier Ltd
Keywords: Dissection
Fiber bridge failure energy
Human ascending thoracic aortic aneurysm
Micro-architecture
Multi-photon microscopy
Radially-oriented collagen
ISSN: 219290
Author Scopus IDs: 22986621300
35321222100
22235590100
7007069675
7202014965
7005301469
Author Affiliations: Tsamis, A., Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Pal, S., Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States
Phillippi, J.A., Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States, Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Gleason, T.G., Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States, Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Maiti, S., Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States
Vorp, D.A., Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States, Surgery, University of Pittsburgh, Pittsburgh, PA, United States, Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Corresponding Author: Maiti, S.; Departments of Bioengineering, University of PittsburghUnited States
Appears in Collections:Journal Publications [ME]

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