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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1122
Title: Osteoconductive Amine-Functionalized Graphene-Poly(methyl methacrylate) Bone Cement Composite with Controlled Exothermic Polymerization
Authors: Sharma R.
Kapusetti G.
Bhong S.Y.
Roy P.
Singh S.K.
Singh S.
Balavigneswaran C.K.
Mahato K.K.
Ray B.
Maiti P.
Misra N.
Published in: Bioconjugate Chemistry
Abstract: Bone cement has found extensive usage in joint arthroplasty over the last 50 years; still, the development of bone cement with essential properties such as high fatigue resistance, lower exothermic temperature, and bioactivity has been an unsolved problem. In our present work, we have addressed all of the mentioned shortcomings of bone cement by reinforcing it with graphene (GR), graphene oxide (GO), and surface-modified amino graphene (AG) fillers. These nanocomposites have shown hypsochromic shifts, suggesting strong interactions between the filler material and the polymer matrix. AG-based nanohybrids have shown greater osteointegration and lower cytotoxicity compared to other nanohybrids as well as pristine bone cement. They have also reduced oxidative stress on cells, resulting in calcification within 20 days of the implantation of nanohybrids into the rabbits. They have significantly reduced the exothermic curing temperature to body temperature and increased the setting time to facilitate practitioners, suggesting that reaction temperature and settling time can be dynamically controlled by varying the concentration of the filler. Thermal stability and enhanced mechanical properties have been achieved in nanohybrids vis-à-vis pure bone cement. Thus, this newly developed nanocomposite can create natural bonding with bone tissues for improved bioactivity, longer sustainability, and better strength in the prosthesis. © 2017 American Chemical Society.
Citation: Bioconjugate Chemistry (2017), 28(9): 2254-2265
URI: https://doi.org/10.1021/acs.bioconjchem.7b00241
http://repository.iitr.ac.in/handle/123456789/1122
Issue Date: 2017
Publisher: American Chemical Society
ISSN: 10431802
Author Scopus IDs: 57212897567
37064570000
57195722847
35509207200
56373951200
56510560300
55596915400
57195727431
7201965442
7005310744
7102697703
Author Affiliations: Sharma, R., School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India
Kapusetti, G., Department of Medical Devices, National Institute of Pharmaceutical Education and Research, Ahmedabad, 380054, India
Bhong, S.Y., Department of Medical Devices, National Institute of Pharmaceutical Education and Research, Ahmedabad, 380054, India
Roy, P., Department of Biotechnology, Indian Institute of Technology, Roorkee, 247667, India
Singh, S.K., Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
Singh, S., Department of Chemistry, Banaras Hindu University, Varanasi, 221005, India
Balavigneswaran, C.K., School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India
Mahato, K.K., School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India
Ray, B., Department of Chemistry, Banaras Hindu University, Varanasi, 221005, India
Maiti, P., School of Materials Science and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India
Misra, N., School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India
Funding Details: †School of Biomedical Engineering and ‡School of Materials Science and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, India §Department of Medical Devices, National Institute of Pharmaceutical Education and Research, Ahmedabad 380054, India ?Department of Biotechnology, Indian Institute of Technology, Roorkee 247667, India ?Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India #Department of Chemistry, Banaras Hindu University, Varanasi 221005, India
Corresponding Author: Misra, N.; School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu UniversityIndia; email: nmishra.bme@itbhu.ac.in
Appears in Collections:Journal Publications [BT]

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