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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/11144
Title: Control of shape and size of poly (lactic acid) microspheres based on surfactant and polymer concentration
Authors: Singh B.
Singh P.
Sutherland A.J.
Pal K.
Published in: Materials Letters
Abstract: Biodegradable, poly (lactic acid) (PLA) microspheres have been synthesized via solvent evaporation method using ultrasonic homogenizer as emulsifier. The effect of added surfactant, PVA [poly (vinyl alcohol)], and PLA concentration on the shape and size of the resultant PLA microspheres has been studied. The prime objective of this work was to identify an optimal PVA/PLA concentration to prepare PLA microsphere with a size distribution of 1–2 micrometers as in many literature it has been reported as ideal range of size for non-endocytosis-mediated cellular drug delivery. In this pursuit it was found that an optimal concentration of 2.5% w/v of PVA into water and 2.5% w/v PLA into DCM [Dichloromethane] is suitable to create PLA microspheres with a size distribution of 1–2 micrometers. The PLA microspheres were characterized by FESEM to assess their shape and size. FT-IR analysis (Supplementary data) was used to assess the functional groups present in the PLA microspheres, whilst zeta-potential measurements (Supplementary data) provided insight into the likely dispersion properties of the microspheres in aqueous media. © 2017
Citation: Materials Letters (2017), 195(): 48-51
URI: https://doi.org/10.1016/j.matlet.2017.02.068
http://repository.iitr.ac.in/handle/123456789/11144
Issue Date: 2017
Publisher: Elsevier B.V.
Keywords: FESEM
FT-IR spectroscopy
Microspheres
Poly (lactic acid) (PLA)
Probe-based ultrasonication
ISSN: 0167577X
Author Scopus IDs: 57208724623
57203789969
7103407073
26427760700
Author Affiliations: Singh, B., Center of Nanotechnology, IIT Roorkee, Roorkee, 247667, India
Singh, P., Center of Nanotechnology, IIT Roorkee, Roorkee, 247667, India
Sutherland, A.J., Aston Materials Centre, Aston University, Birmingham, B4 7ET, United Kingdom
Pal, K., Center of Nanotechnology, IIT Roorkee, Roorkee, 247667, India, Department of Mechanical and Industrial Engineering, IIT Roorkee, Roorkee, 247667, India
Funding Details: This work is supported by training and financial assistant provided by The Royal Society, London under the International Exchange Scheme-2014/R2 and MHRD fellowship India.
Corresponding Author: Pal, K.; Department of Mechanical and Industrial Engineering, IIT RoorkeeIndia; email: pl_kshk@yahoo.co.in
Appears in Collections:Journal Publications [ME]

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