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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/11068
Title: Cardiac Manifestations in HIV Infected Children
Authors: Singh P.
Hemal A.
Agarwal S.
Kumar D.
Published in: Indian Journal of Pediatrics
Abstract: Objective: To determine the occurrence of cardiac involvement in HIV infected children and describe its spectrum using non-invasive tests like ECG and 2-Dimensional Echocardiography (2-D ECHO).Methods: A cross sectional observational study was carried out on 100 HIV infected children between 1 and 18 y of age. The various cardiac manifestations were determined clinically, by electrocardiogram (ECG) and 2-D echocardiography.Results: Seventy four percent of the patients were males with a mean age of 9.62 ± 3.62 y. Seventy seven percent children were in WHO stage I. Sixty five percent did not have significant immune suppression. Eighty six percent children were on HAART (mean duration- 35.12 ± 29.48 mo). Fifty nine percent of children were symptomatic and only nine patients were clinically suspected to have cardiac involvement. ECG abnormalities were found in 14 % cases. The most common abnormal echocardiographic finding was left ventricular diastolic dysfunction by tissue Doppler (E/E′) observed in 64 % cases followed by systolic dysfunction (37 %), abnormal left ventricular mass (29 %), pericardial effusion (2 %) and dilated cardiomyopathy (2 %); 64.2 % cases with left ventricular systolic dysfunction (LVSD) were in WHO stage III.Conclusions: Involvement of heart in HIV/AIDS is mostly subclinical. HIV myocarditis produces systolic as well as diastolic dysfunction. At present, echocardiography remains the only tool for identifying heart involvement in HIV-infected children. Early diagnosis and intervention may halt the progression of the disease, thereby preventing morbidity and mortality. © 2014, Dr. K C Chaudhuri Foundation.
Citation: Indian Journal of Pediatrics (2015), 82(3): 230-234
URI: https://doi.org/10.1007/s12098-014-1481-9
http://repository.iitr.ac.in/handle/123456789/11068
Issue Date: 2015
Publisher: Springer
Keywords: Cardiovascular manifestaions
Children
HIV
India
ISSN: 195456
Author Scopus IDs: 55568517788
36522946000
55581476200
57202478211
Author Affiliations: Singh, P., Department of Pediatrics and Neonatology, PGIMER and Ram Manohar Lohia Hospital, Delhi, 110001, India
Hemal, A., Department of Pediatrics and Neonatology, PGIMER and Ram Manohar Lohia Hospital, Delhi, 110001, India
Agarwal, S., Department of Pediatrics and Neonatology, PGIMER and Ram Manohar Lohia Hospital, Delhi, 110001, India
Kumar, D., Division of Pediatric Cardiology, Department of Pediatrics and Neonatology, PGIMER and Ram Manohar Lohia Hospital, Delhi, India
Corresponding Author: Hemal, A.; Department of Pediatrics and Neonatology, PGIMER and Ram Manohar Lohia HospitalIndia
Appears in Collections:Journal Publications [ME]

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