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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1094
Title: Synthesis of fluorescent MOFs: Live-cell imaging and sensing of a herbicide
Authors: Mohanty A.
Singh U.P.
Butcher R.J.
Das N.
Roy P.
Published in: CrystEngComm
Abstract: Various zinc and cadmium containing metal-organic frameworks using the semi-rigid 1,1?-(anthracene-9,10-diylbis(methylene))bis(pyridin-1-ium-4-olate) ligand (L = AHP) and various sulfonic acid analogs [1,5-naphthalenedisulfonic acid (1,5-NDS), 3-sulfobenzoic acid (3-SBA), 4-sulfobenzoic acid (4-SBA), 5-sulfosalicylic acid (SSA), 5-sulfoisophthalic acid (SIA) and 2,6-naphthalenedisulfonic acid (2,6-NDS)] have been synthesized by a hydrothermal method. They have been characterized by powder X-ray diffraction thermogravimetric analysis and single crystal X-ray diffraction methods. The X-ray studies showed that MOF2, 4, and 8 have two dimensional architectures whereas 1, 3, 5, 6 and 7 have three-dimensional structures. The topological analysis demonstrated that all the zinc-containing MOFs have a hexagonal (hcb) net topology with the point symbol of the framework being {63} whereas cadmium-containing MOF4 has an sql net topology with the point symbol of the framework being {44·62} and MOF5 has a hcb net topology with the point symbol of the framework being {63}. Since all synthesized MOFs have fluorescence properties, they have been used as imaging agents for MCF7 cells. The cytotoxic experiments show that more than 92% cells survive at the dose 100 ?g ml-1. The cell imaging results show that the MOF particles were found in the cytoplasm rather than in the nucleus and these can be used further as a conjugate with any known anti-cancer drugs in cellular distribution. The emission properties of these MOFs have been utilized for the detection of a herbicide (simazine) as well as nitroaromatic compounds. The quenching constant for PA (picric acid) in MOF7 was found to be 5.01 × 104 M-1, which may be due to the interaction of picric acid and co-ligands present in MOF7. © The Royal Society of Chemistry.
Citation: CrystEngComm (2020), 22(26): 4468-4477
URI: https://doi.org/10.1039/d0ce00490a
http://repository.iitr.ac.in/handle/123456789/1094
Issue Date: 2020
Publisher: Royal Society of Chemistry
ISSN: 14668033
Author Scopus IDs: 57211874489
57216102257
7201947292
57209505172
35509207200
Author Affiliations: Mohanty, A., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Singh, U.P., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Butcher, R.J., Department of Chemistry, Howard University, Washington, DC 20059, United States
Das, N., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Roy, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Funding Details: The authors are grateful to the BRNS (DAE), Mumbai, India for financial assistance. A. Mohanty gratefully acknowledges IIT Roorkee for the MHRD fellowship.
Corresponding Author: Singh, U.P.; Department of Chemistry, Indian Institute of Technology RoorkeeIndia; email: udaipfcy@iitr.ac.in
Appears in Collections:Journal Publications [BT]

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