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Title: A Review on Atherosclerotic Biology, Wall Stiffness, Physics of Elasticity, and Its Ultrasound-Based Measurement
Authors: Patel A.K.
Suri H.S.
Singh J.
Kumar D.
Shafique S.
Nicolaides A.
Jain S.K.
Saba L.
Gupta A.
Laird J.R.
Giannopoulos A.
Suri J.S.
Published in: Current Atherosclerosis Reports
Abstract: Functional and structural changes in the common carotid artery are biomarkers for cardiovascular risk. Current methods for measuring functional changes include pulse wave velocity, compliance, distensibility, strain, stress, stiffness, and elasticity derived from arterial waveforms. The review is focused on the ultrasound-based carotid artery elasticity and stiffness measurements covering the physics of elasticity and linking it to biological evolution of arterial stiffness. The paper also presents evolution of plaque with a focus on the pathophysiologic cascade leading to arterial hardening. Using the concept of strain, and image-based elasticity, the paper then reviews the lumen diameter and carotid intima-media thickness measurements in combined temporal and spatial domains. Finally, the review presents the factors which influence the understanding of atherosclerotic disease formation and cardiovascular risk including arterial stiffness, tissue morphological characteristics, and image-based elasticity measurement. © 2016, Springer Science+Business Media New York.
Citation: Current Atherosclerosis Reports (2016), 18(12): -
Issue Date: 2016
Publisher: Current Medicine Group LLC 1
Keywords: Atherosclerosis
Risk stratification
Tissue characterization
ISSN: 15233804
Author Scopus IDs: 57191916635
Author Affiliations: Patel, A.K., Department of Computer Engineering, NIT, Kurukshetra, India
Suri, H.S., Mira Loma, Sacramento, CA, United States
Singh, J., Department of Computer Engineering, NIT, Kurukshetra, India
Kumar, D., Point-of-Care Devices, Global Biomedical Technologies, Inc., Roseville, CA, United States
Shafique, S., CorVasc Vascular Laboratory, Indianapolis, IN, United States
Nicolaides, A., Vascular Diagnostic Center, University of Cyprus, Nicosia, Cyprus
Jain, S.K., Department of Computer Engineering, NIT, Kurukshetra, India
Saba, L., Department of Radiology, University of Cagliari, Cagliari, Italy
Gupta, A., Radiology Department, Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States
Laird, J.R., UC Davis Vascular Center, University of California, Davis, CA, United States
Giannopoulos, A., Department of Vascular Surgery, Imperial College, London, United Kingdom
Suri, J.S., Vascular Diagnostic Center, University of Cyprus, Nicosia, Cyprus, Monitoring and Diagnostic Division, AtheroPointâ„¢, Roseville, CA, United States, Department of Electrical Engineering, University of Idaho (Affl.), Moscow, ID, United States, Diagnosis and Stroke Monitoring Division, AtheroPointâ„¢, Roseville, CA, United States
Corresponding Author: Suri, J.S.; Diagnosis and Stroke Monitoring Division, AtheroPointâ„¢United States; email:
Appears in Collections:Journal Publications [ME]

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