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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/10791
Title: A mechanistic model on the role of "radially-running" collagen fibers on dissection properties of human ascending thoracic aorta
Authors: Pal, Siladitya
Tsamis A.
Pasta S.
D'Amore A.
Gleason T.G.
Vorp D.A.
Maiti S.
Published in: Journal of Biomechanics
Abstract: Aortic dissection (AoD) is a common condition that often leads to life-threatening cardiovascular emergency. From a biomechanics viewpoint, AoD involves failure of load-bearing microstructural components of the aortic wall, mainly elastin and collagen fibers. Delamination strength of the aortic wall depends on the load-bearing capacity and local micro-architecture of these fibers, which may vary with age, disease and aortic location. Therefore, quantifying the role of fiber micro-architecture on the delamination strength of the aortic wall may lead to improved understanding of AoD. We present an experimentally-driven modeling paradigm towards this goal. Specifically, we utilize collagen fiber micro-architecture, obtained in a parallel study from multi-photon microscopy, in a predictive mechanistic framework to characterize the delamination strength. We then validate our model against peel test experiments on human aortic strips and utilize the model to predict the delamination strength of separate aortic strips and compare with experimental findings. We observe that the number density and failure energy of the radially-running collagen fibers control the peel strength. Furthermore, our model suggests that the lower delamination strength previously found for the circumferential direction in human aorta is related to a lower number density of radially-running collagen fibers in that direction. Our model sets the stage for an expanded future study that could predict AoD propagation in patient-specific aortic geometries and better understand factors that may influence propensity for occurrence. © 2014 Elsevier Ltd.
Citation: Journal of Biomechanics (2014), 47(5): 981-988
URI: https://doi.org/10.1016/j.jbiomech.2014.01.005
http://repository.iitr.ac.in/handle/123456789/10791
Issue Date: 2014
Publisher: Elsevier Ltd
Keywords: Aorta
Collagen fibers
Dissection
Fiber bridge failure model
Peel force
ISSN: 219290
Author Scopus IDs: 35321222100
22986621300
55338819100
35487173200
7007069675
7005301469
7202014965
Author Affiliations: Pal, S., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States
Tsamis, A., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, University of Pittsburgh, Center for Vascular Remodeling and Regeneration, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Pasta, S., Fondazione Ri.MED, University of Palermo, Palermo, Italy, DICGM University of Palermo, Palermo, Italy
D'Amore, A., McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States, Fondazione Ri.MED, University of Palermo, Palermo, Italy, DICGM University of Palermo, Palermo, Italy
Gleason, T.G., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States, University of Pittsburgh, Center for Vascular Remodeling and Regeneration, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Vorp, D.A., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States, University of Pittsburgh, Center for Vascular Remodeling and Regeneration, Pittsburgh, PA, United States, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Maiti, S., Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States
Funding Details: The authors gratefully acknowledge funding support of this work by the Swiss National Science Foundation Fellowships for Advanced Researcher Nos. PA00P2_139684 and PA00P2_145399 (Dr. Tsamis), by the Fondazione Ri.MED (Drs. D'Amore and Pasta), by the NIH R01 HL109132 (Drs. Gleason and Vorp), and by the University of Pittsburgh's Department of Cardiothoracic Surgery (Dr. Vorp). The authors also thank Mr. Ryan Koch for his help in generating image-based analysis data. Appendix
Corresponding Author: Maiti, S.; Department of Bioengineering, University of Pittsburgh, 207 Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, United States; email: spm54@pitt.edu
Appears in Collections:Journal Publications [ME]

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