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Title: Label-free fluorescence "turn-on" detection of SO32- by gold nanoclusters: Integration in a hydrogel platform and intracellular detection
Authors: Sachdev A.
Raj R.
Matai I.
Kumar V.
Gopinath P.
Mishra S.
Published in: Analytical Methods
Abstract: A facile approach for the fluorescence based detection of sulfite (SO32-) using gold nanoclusters (Au NCs) has been reported. The detection assay relies on the effective quenching of the fluorescence of Au NCs in the presence of Cu2+, which could eventually be recovered upon the addition of SO32-. The proposed Cu2+ assisted fluorescence "turn-on" detection method for SO32- was highly sensitive and demonstrated a linear response towards SO32- within the desired concentration range. Importantly, the sensing system possessed high selectivity for SO32- compared to other competitive anionic analytes, allowing for an analytically robust and reliable detection. Further, fluorescent Au NC-hydrogels were developed, which present a way forward for solid sensing platforms for the detection of SO32- in aqueous solutions, making it a meaningful approach for instrument-free and visual monitoring. Owing to their excellent analytical characteristics, Au NCs were successfully employed for intracellular SO32- detection. Therefore, the present study encompasses the manifold detection aspects of Au NC based sensors. This journal is © The Royal Society of Chemistry.
Citation: Analytical Methods(2019), 11(9): 1284-1288
Issue Date: 2019
Publisher: Royal Society of Chemistry
ISSN: 17599660
Author Scopus IDs: 55853618300
Author Affiliations: Sachdev, A., Ubiquitous Analytical Techniques Division, CSIR-Central Scientific Instruments Organization (CSIR-CSIO), Chandigarh, India, Academy of Scientific and Innovative Research (AcSIR-CSIO), Chandigarh, India
Raj, R., Ubiquitous Analytical Techniqu
Corresponding Author: Sachdev, A.; Ubiquitous Analytical Techniques Division, CSIR-Central Scientific Instruments Organization (CSIR-CSIO)India; email:
Appears in Collections:Journal Publications [BT]

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