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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1001
Title: Transcription factor Foxo1 is essential for IL-9 induction in T helper cells
Authors: Malik S.
Sadhu S.
Elesela S.
Pandey R.P.
Chawla A.S.
Sharma D.
Panda L.
Rathore D.
Ghosh B.
Ahuja V.
Awasthi A.
Published in: Nature Communications
Abstract: Interleukin 9 (IL-9)-producing helper T (Th9) cells have a crucial function in allergic inflammation, autoimmunity, immunity to extracellular pathogens and anti-tumor immune responses. In addition to Th9, Th2, Th17 and Foxp3+ regulatory T (Treg) cells produce IL-9. A transcription factor that is critical for IL-9 induction in Th2, Th9 and Th17 cells has not been identified. Here we show that the forkhead family transcription factor Foxo1 is required for IL-9 induction in Th9 and Th17 cells. We further show that inhibition of AKT enhances IL-9 induction in Th9 cells while it reciprocally regulates IL-9 and IL-17 in Th17 cells via Foxo1. Mechanistically, Foxo1 binds and transactivates IL-9 and IRF4 promoters in Th9, Th17 and iTreg cells. Furthermore, loss of Foxo1 attenuates IL-9 in mouse and human Th9 and Th17 cells, and ameliorates allergic inflammation in asthma. Our findings thus identify that Foxo1 is essential for IL-9 induction in Th9 and Th17 cells. © 2017 The Author(s).
Citation: Nature Communications(2017), 8(1): -
URI: https://doi.org/10.1038/s41467-017-00674-6
http://repository.iitr.ac.in/handle/123456789/1001
Issue Date: 2017
Publisher: Nature Publishing Group
ISSN: 20411723
Author Scopus IDs: 57075608100
57196017628
55372728100
57213791876
57193537070
57211529032
55917250100
57196026716
57212449576
57206494872
7006541407
Author Affiliations: Malik, S., Center for Human Microbial Ecology, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone Gurgaon-Faridabad Expressway, Faridabad, Haryana, 121 001, India
Sadhu, S., Center for Human Microbial Ecolo
Funding Details: We thank to Vijay K. Kuchroo, Harvard Medical School, Boston, MA for providing Foxo1 conditional and Il23r?/? mice and his critical comments on manuscript. We thank Satyajit Rath (National Institute of Immunology, New Delhi, India) for providing mice; Raj
Corresponding Author: Awasthi, A.; Center for Human Microbial Ecology, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone Gurgaon-Faridabad ExpresswayIndia; email: aawasthi@thsti.res.in
Appears in Collections:Journal Publications [BT]

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