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dc.contributor.authorMalik S.-
dc.contributor.authorSadhu S.-
dc.contributor.authorElesela S.-
dc.contributor.authorPandey R.P.-
dc.contributor.authorChawla A.S.-
dc.contributor.authorSharma D.-
dc.contributor.authorPanda L.-
dc.contributor.authorRathore D.-
dc.contributor.authorGhosh B.-
dc.contributor.authorAhuja V.-
dc.contributor.authorAwasthi A.-
dc.date.accessioned2020-09-30T11:32:21Z-
dc.date.available2020-09-30T11:32:21Z-
dc.date.issued2017-
dc.identifier.citationNature Communications(2017), 8(1): --
dc.identifier.issn20411723-
dc.identifier.other28993609-
dc.identifier.urihttps://doi.org/10.1038/s41467-017-00674-6-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/1001-
dc.description.abstractInterleukin 9 (IL-9)-producing helper T (Th9) cells have a crucial function in allergic inflammation, autoimmunity, immunity to extracellular pathogens and anti-tumor immune responses. In addition to Th9, Th2, Th17 and Foxp3+ regulatory T (Treg) cells produce IL-9. A transcription factor that is critical for IL-9 induction in Th2, Th9 and Th17 cells has not been identified. Here we show that the forkhead family transcription factor Foxo1 is required for IL-9 induction in Th9 and Th17 cells. We further show that inhibition of AKT enhances IL-9 induction in Th9 cells while it reciprocally regulates IL-9 and IL-17 in Th17 cells via Foxo1. Mechanistically, Foxo1 binds and transactivates IL-9 and IRF4 promoters in Th9, Th17 and iTreg cells. Furthermore, loss of Foxo1 attenuates IL-9 in mouse and human Th9 and Th17 cells, and ameliorates allergic inflammation in asthma. Our findings thus identify that Foxo1 is essential for IL-9 induction in Th9 and Th17 cells. © 2017 The Author(s).-
dc.language.isoen_US-
dc.publisherNature Publishing Group-
dc.relation.ispartofNature Communications-
dc.titleTranscription factor Foxo1 is essential for IL-9 induction in T helper cells-
dc.typeArticle-
dc.scopusid57075608100-
dc.scopusid57196017628-
dc.scopusid55372728100-
dc.scopusid57213791876-
dc.scopusid57193537070-
dc.scopusid57211529032-
dc.scopusid55917250100-
dc.scopusid57196026716-
dc.scopusid57212449576-
dc.scopusid57206494872-
dc.scopusid7006541407-
dc.affiliationMalik, S., Center for Human Microbial Ecology, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone Gurgaon-Faridabad Expressway, Faridabad, Haryana, 121 001, India-
dc.affiliationSadhu, S., Center for Human Microbial Ecolo-
dc.description.fundingWe thank to Vijay K. Kuchroo, Harvard Medical School, Boston, MA for providing Foxo1 conditional and Il23r?/? mice and his critical comments on manuscript. We thank Satyajit Rath (National Institute of Immunology, New Delhi, India) for providing mice; Raj-
dc.description.correspondingauthorAwasthi, A.; Center for Human Microbial Ecology, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone Gurgaon-Faridabad ExpresswayIndia; email: aawasthi@thsti.res.in-
Appears in Collections:Journal Publications [BT]

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